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Read the PDF of Future Science Series: Aneuploidy—The Chromosomal Imbalance that Leads to Cancer with David Rasnick, PhD
By Ulrike Granögger
To date, the prevalent approach to understanding and curing cancer has been to sequence the cancer genome and find the responsible oncogene(s). But this approach has turned out to be futile, with many studies showing great heterogeneity within individual tumors. In fact, no cancer cell is alike; even within the same tumor, gene mutations are variegated and manifold.
The search for the “bad gene” and attempts to correct it by gene-therapeutic methods such as Crispr-Cas9 and mRNA injections are looking like the search for the proverbial needle in the haystack.
There is one thing, however, that all tumors have in common: their chromosomes are out of balance. While normal cells contain a double set of chromosomes (diploid cells), all cancerous cells have more than the usual chromosomes with many of them broken, disproportionate, or missing.
While David Rasnick and Peter Duesberg became famous for their independent thoughts on AIDS, demonstrating that the hypothesis of HIV causing AIDS is wrong, their scientific passion belonged to the field of oncology and the development of the “aneuploidy theory of cancer.”
In this Special Solari Report for our Future Science Series, David Rasnick offers an in-depth explanation of the aneuploidy hypothesis and what it means in terms of current developments in gene-based therapies.